ITB

Chemical Name: N-(4-Bromophenyl)-7-(4-chlorophenyl)-7H-indazolo[2',3':1,5][1,2,4]triazolo[4,3-a][1,3,5]benzotriazepin-6-amine
CAS No. 312328-53-3
项目整合开发状态: Preclinical
项目研究机构: Universidad de Murcia (Originator), Universidad de Valencia (Originator)
合成路线:The condensation between 2-azidobenzaldehyde (I) and 2-azidoaniline (II) produces the bis-azido imine (III),which upon coupling to polymer bound triphenylphosphine gives rise to the indazole derivative (IV).Aza-Wittig condensation of (IV) with 4-chlorophenyl isothiocyanate (V) generates the intermediate carbodiimide (VI) which spontaneously cyclizes to the triazoloindazole (VII).Subsequent condensation of (VII) with 4-bromophenyl isothiocyanate (VIII) furnishes the target pentacyclic compound.