TPFA, Thiovir
Chemical Name: Hydroxy(sulfanyl)phosphinecarboxylic acid oxide; Thiophosphonoformic acid
CAS No. 102805-86-7, 99107-93-4 (triNa salt)
项目整合开发状态: Preclinical
项目研究机构: University of Southern California (Originator), Adventrx Pharmaceuticals (Licensee), National Cancer Institute (Codevelopment)
合成路线:The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II),which is hydrolyzed with 10 N NaOH.
📌 参考资料/链接：
参考文献标题:Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
文献作者:McKenna,C.E.
参考来源:US 5183812
📄 详细内容
合成路线:The reaction of phosphonoformic acid trimethyl ester (I) with Lawesson's reagent in refluxing acetonitrile gives the thiophosphonate (II),which is hydrolyzed with 10 N NaOH.
参考文献标题:Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
文献作者:McKenna,C.E.
参考来源:US 5072032
产品链接: CAS No.99107-93-4››