AP-2238

Chemical Name: 3-[4-(N-Benzyl-N-methylaminomethyl)phenyl]-6,7-dimethoxy-2H-1-benzopyran-2-one
CAS No. 553681-56-4
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Bologna (Originator)
合成路线:Partial demethylation of 2,4,5-trimethoxybenzaldehyde (I) with BCl3 gives 2-hydroxy-4,5-dimethoxybenzaldehyde (II),which is condensed with the sodium salt of p-tolylacetic acid (III) in boiling acetic anhydride to afford the coumarin derivative (IV).Benzylic halogenation of (IV) with N-bromosuccinimide in the presence of a catalytic amount of benzoyl peroxide yields bromide (V),which is finally condensed with N-methyl benzylamine (VI) to afford the desired compound.