新产品编号:982931

Chemical Name: 1-[1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl]ethanone
CAS No. 66040-38-8
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Catanzaro (Originator), Universit?degli Studi di Messina (Originator), University of London (Originator)
合成路线:Condensation between 2-(3,4-dimethoxyphenyl)ethylamine (I) and 4-chlorobenzaldehyde (II) in refluxing toluene affords imine (III).Then,Pictet-Spengler cyclization of imine (III) in the presence of trifluoroacetic acid leads to the tetrahydroisoquinoline (IV).This is further acylated in boiling acetic anhydride to produce the target acetamide.