新产品编号:786763
Chemical Name: Acetic acid trans-1-(6-chrysenyl)-2-oxo-4-phenylazetidin-3-yl ester
CAS No. 302595-58-0
项目整合开发状态: Preclinical
项目研究机构: M.D. Anderson Cancer Center (Originator)
合成路线:The title trans beta-lactam is obtained by condensation of imine (I) with acetyloxyacetyl chloride (II) in the presence of Et3N in cold CH2Cl2 under Staudinger reaction conditions.(1,2)
📌 参考资料/链接：
参考文献标题:Stereoselective synthesis of beta-lactams with polyaromatic imines: Entry to new and novel anticancer agents
文献作者:Banik,I.; Becker,F.F.; Banik,B.K.
参考来源:J Med Chem 2003,46(1),12
📄 详细内容
合成路线:The title trans beta-lactam is obtained by condensation of imine (I) with acetyloxyacetyl chloride (II) in the presence of Et3N in cold CH2Cl2 under Staudinger reaction conditions.(1,2)
参考文献标题:Unprecedented stereoselectivity in the Staudinger reaction with polycyclic aromatic imines
文献作者:Banik,N.K.; Becker,F.F.
参考来源:Tetrahedron Lett 2000,41(34),6551