EPH-350

Chemical Name: 1-(5-Methylpyridin-2-yl)ethanone (1-methyl-1H-benzimidazol-2-yl)hydrazone
CAS No. 379226-93-4
项目整合开发状态: Biological Testing
项目研究机构: Universit鋞 Innsbruck (Originator)
合成路线:3-Picoline (I) is oxidized to the corresponding N-oxide (II) by means of peracetic acid.Condensation of (II) with dimethylcarbamoyl chloride furnishes carbamate (III),which is then reacted with cyanotrimethylsilane,producing 2-cyano-5-methylpyridine (IV).Subsequent addition of methylmagnesium iodide to the cyanopyridine (IV) gives rise to the pyridyl ketone (V).

合成路线:Alkylation of 2-chlorobenzimidazole (VI) with iodomethane and NaOH leads to 2-chloro-1-methylbenzimidazole (VII).The 2-chloro group of (VII) is then displaced with hydrazine hydrate to afford hydrazine (VIII).Finally,condensation between ketone (V) and hydrazine (VIII) gives rise to the target hydrazone.