NU-7279

Chemical Name: 2-(4-Morpholinyl)-6-[4-(1-naphthyl)phenyl]-4H-thiopyran-4-one
CAS No. 500169-73-3
项目整合开发状态: Biological Testing
项目研究机构: Cancer Research Technology (Originator), Kudos Pharmaceuticals (Originator)
合成路线:Claisen condensation of 4-bromoacetophenone (I) with ethyl acetate provides diketone (II).Subsequent reaction of (II) with carbon disulfide in the presence of LDA leads to thiopyranone thiol (III).Alkylation of thiol (III) with iodoethane and K2CO3 affords sulfide (IV),which is further oxidized to sulfoxide (V) by means of mCPBA.Displacement of either sulfide (IV) or sulfoxide (V) with morpholine gives rise to the morpholinyl thiopyranone (VI).Finally,Suzuki coupling between aryl bromide (VI) and 2-naphthaleneboronic acid (VII) produces the target compound