新产品编号:859535
Chemical Name: 1-Butyl-9-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)-3-isobutyl-1,4,9-triazaspiro[5.5]undecane-2,5-dione
CAS No. 342910-23-0
项目整合开发状态: Biological Testing
项目研究机构: Ono (Originator)
合成路线:The Ugi reaction between 1-benzodioxanylmethyl-4-piperidone (I),N-Boc-leucine (II),butylamine (III),and isonitrile-bound resin produces the diamide resin (IV).Removal of the N-Boc group of (IV),followed by cyclative cleavage of the deprotected amino amide resin (V),affords the target spiro diketopiperazine derivative.
📌 参考资料/链接:
参考文献标题:Discovery of potent CCR5-antagonistic anti-HIV agents using newly generated GPCR-targeted combinatorial library
文献作者:Habashita,H.; et al.
参考来源:22nd Symp Med Chem (Nov 27 2002,Shizuoka) 2002,Abst 1P-05