Epidoxoform
Chemical Name: 10,10'-[(1S,3R,4aS,7aR,8S,10R,11aS,14aR)-1,8-Dimethylperhydro-5,12-methanodipyrano[4,3-d:4',3'-i][1,6,3,8]dioxadiazecin-3,10-diyl]bis(oxy)bis[(6aS,11S)-8-glycoloyl-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione]
CAS No. 205499-28-1
项目整合开发状态: Preclinical
项目研究机构: University of Colorado (Originator)
合成路线:The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6.(1-3)
📌 参考资料/链接：
参考文献标题:Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity: Cpds.,compsns.and methods
文献作者:Taatjes,D.J.; Fenick,D.J.; Koch,T.H.(University Technology Corp.)
参考来源:JP 2002514213; US 6677309; WO 9846598
📄 详细内容
合成路线:The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6.(1-3)
参考文献标题:Evaluation of the epidoxorubicin-formaldehyde conjugate,epidoxoform,in a mouse mammary carcinoma model
文献作者:Dernell,W.S.; Powers,B.E.; Taatjes,D.J.; Cogan,P.; Gaudiano,G.; Koch,T.H.
参考来源:Cancer Invest 2002,20(5-6),713
合成路线:The title compound is obtained by dimerization of epidoxorubicin hydrochloride (I) in the presence of an excess of formaldehyde in a triethylammonium acetate buffer at pH 6.(1-3)
参考文献标题:Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells
文献作者:Taatjes,D.J.; Fenick,D.J.; Koch,T.H.
参考来源:J Med Chem 1998,41(8),1306