Chemical Name: 7-[4-[4-[5(S)-(Acetamidomethyl)-2-oxooxazolidin-3-yl]-2-fluorophenyl]piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 444335-12-0
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator), Morphochem (Not Determined)
合成路线:The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.
📄 详细内容
合成路线:The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.
参考文献标题:Synthesis and antibacterial action of novel quinolone-linked oxazolidinones
文献作者:Locher,H.H.; Specklin,J.; Borer,Y.; Brohammer,S.; Schroeder,S.; Sigwalt,C.; Hubschwerlen,C.
参考来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002,San Diego) 2002,Abst F-1317
合成路线:The title adduct is prepared by condensation between the piperazinyl oxazolidinone derivative (I) and chloroquinoline (II) in hot N-methylpyrrolidinone.
参考文献标题:Novel oxazolidinone-quinolone hybrid antimicrobials
文献作者:Gordeev,M.F.; Hackbarth,C.; Barbachyn,M.R.; Bannit,L.S.; Gage,J.R.; Luehr,G.W.; Gomez,M.; Trias,J.; Morin,S.E.; Zurenko,G.E.; Parker,C.N.; Evans,J.M.; White,R.J.; Patel,D.V.
参考来源:Bioorg Med Chem Lett 2003,13(23),4213