BMS-411886

Chemical Name: N-[1-Carbamoyl-2-[N-(2-hydroxyethyl)-N-methylamino]ethyl]-2-[(1S,18S,21E,28S,29R,30S)-30-[(2S,4S,5R,6S)-5-(dimethylamino)-4-hydroxy-4,6-dimethyltetrahydropyran-2-yloxy]-9,52-dihydroxy-18-[1(R)-hydroxyethyl]-21-(1-methoxyethylidene)-16,19,26,31,42,46-hexaoxo-32,43,54-trioxa-3,13,23,49-tetrathia-7,17,20,27,45,51,52,55,56,57-decaazadecacyclo[26.16.6.2(29,40).1(2,5).1(12,15).1(22,25).1(38,41).1(47,50).0(6,11).0(34,39)]heptapentaconta-2(57),4,6,8,10,12(56),14,22(55),24,34,36,38,40,47,50-pentadecaen-8-yl]thiazole-4-carboxamide
CAS No. 401825-64-7 (racemic, diHCl), 401827-18-7 (stereoisomer), 401827-20-1 (stereoisomer)
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:The title compound is prepared using nocathiacin I (I) as the starting material.Michael addition of 2-(methylamino)ethanol (II) to the conjugated amide function of (I) in aqueous solution gives rise to the target diaminopropionamide derivative.