INS-48848
Chemical Name: N-(1-Oxo-2,3,4,9-tetrahydro-1H-beta-carbolin-6-yl)carbamic acid methyl ester; N-(1-Oxo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-6-yl)carbamic acid methyl ester
CAS No. 393835-84-2
项目整合开发状态: Preclinical
项目研究机构: Inspire Pharmaceuticals (Originator)
合成路线:The reduction of 6-nitro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one (I) with H2 over Pd/C in ethanol gives the corresponding 6-amino derivative (II),which is condensed with methyl chloroformate (III) and pyridine to afford the target carbamate.
📌 参考资料/链接:
参考文献标题:Method for reducing intraocular pressure using indole derivs.
文献作者:Yerxa,B.R.; Peterson,W.M.; Pintor,J.J.; Peral,M.A.; Plourde,R.Jr.; Brown,E.G.(Inspire Pharmaceuticals,Inc.; Universidad Complutense de Madrid)
参考来源:WO 0209702