T-226296

Chemical Name: (-)-N-[6-(Dimethylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]-4'-fluorobiphenyl-4-carboxamide
CAS No. 331758-35-1, 331756-51-5 (undefined isomer), 331757-36-9 (undefined isomer monoHCl salt)
项目整合开发状态: Preclinical
项目研究机构: Takeda (Originator)
合成路线:The title amide is prepared by acylation of 6-amino-2-[(dimethylamino)methyl]tetralin hydrochloride (I) with 4'-fluorobiphenyl-4-carboxylic acid (II) in the presence of EDC and HOBt.