CPHPC, Ro-63-8695

Chemical Name: 1-[6-[2(R)-Carboxy-1-pyrrolidinyl]-6-oxohexanoyl]pyrrolidine-2(R)-carboxylic acid; 1,1'-(1,6-Dioxo-1,6-hexanediyl)bis(D-proline)
CAS No. 224624-80-0
项目整合开发状态: Phase II
项目研究机构: Roche (Originator), Royal Free Hospital (Codevelopment)
合成路线:The synthesis of Ro-63-8695 can be performed by first coupling of D-proline-benzylester hydrochloride (I) with adipoyl chloride (II) by means of Et3N in dichloromethane to furnish benzyl 1-[6-[2(R)-carboxy-1-pyrrolidinyl]-6-oxohexanoyl]pyrrolidine-2(R)-carboxylate (III),which is finally hydrogenated over Pd/C in MeOH.