新产品编号:756705

Chemical Name: Phosphoric acid 2(R)-(3-methoxyphenyl)-1(S)-methyl-2-(octanamido)ethyl monoester disodium salt; N-[1(R)-(3-Methoxyphenyl)-2(S)-phosphonoxypropyl]octanamide disodium salt
CAS No. 289051-01-0, 289052-54-6 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Ono (Originator)
合成路线:The chiral amino alcohol (I) is acylated with octanoic acid (II),using EDC and HOBt,to afford amide (III).The lithium alkoxide of (III) is then phosphorylated by dibenzyl phosphorochloridate,yielding phosphate ester (IV).Benzyl groups cleavage in (IV) is effected by catalytic hydrogenation of (IV) over Pd/C to produce acid (V),which is finally converted to the title disodium salt by treatment with NaOH in EtOH.