新产品编号:989259
Chemical Name: 2-Hydroxy-N-(2-hydroxyethyl)-N,N-dimethyl-1-hexadecanaminium bromide
CAS No. 86579-60-4, 126150-49-0 (acetate), 85006-12-8 (cation), 84643-53-8 (chloride), 124591-63-5 (iodide), 85006-13-9 (phosphate)
项目整合开发状态: Biological Testing
项目研究机构: Eastern Virginia Medical School (Originator), Virginia Tech (Originator)
合成路线:Treatment of 1,2-epoxyhexadecane (I) with concentrated HBr at 65 C gives rise to bromohydrin (II).This is then condensed with N,N-dimethyl ethanolamine (III) to produce the title ammonium salt.
📌 参考资料/链接：
参考文献标题:Process for preparing quaternary ammonium cpds.
文献作者:Rutzen,H.(Henkel KgA)
参考来源:DE 3136628; EP 0075066; JP 1983046043; US 4480126
📄 详细内容
合成路线:In a related procedure,halogenation of 1-hexadecene (I) with N-bromosuccinimide in THF/H2O leads to a mixture of regioisomeric bromohydrins (II) and (III).Refluxing of this mixture of bromohydrins with N,N-dimethyl ethanolamine (IV) in MeOH gives rise to the title ammonium salt as the only isomer.
参考文献标题:Spermicidal,anti-HIV,and micellar properties of di- and trihydroxylated cationic surfactants
文献作者:Wong,Y.-L.; et al.
参考来源:Tetrahedron 2002,58(1),45