新产品编号:819985
Chemical Name: 2,6-(Methanoxy[1,4]benzenomethano[1,4]benzenoxymethano[2,6]naphthalenomethanoxy[1,4]benzenomethano[1,4]benzenoxymethano)naphthalene-12,20,37,45-tetracarboxylic acid
CAS No. 327028-14-8
项目整合开发状态: Biological Testing
项目研究机构: Organon (Originator)
合成路线:Fischer esterification of 5,5'-methylene-bis-salicylic acid (I) with methanolic HCl gives the dimethyl ester (II).Alkylation of the phenolic hydroxyls of (II) with 2,6-di(bromomethyl)naphthalene (III) affords the bis-naphthylmethyl ether (IV).Then,macrocyclization of dibromide (IV) with a further molecule of 5,5'-methylene-bis-salicylic acid dimethyl ester (II) produces the tetraoxacyclophane derivative (V).Finally,basic hydrolysis of the methyl ester groups of (V) produces the title tetracarboxylic acid.
📌 参考资料/链接：
参考文献标题:Use of chemical chelators as reversal agents for drug-induced neuromuscular block
文献作者:Muir,A.W.; Rees,D.; Bom,A.H.A.(Akzo Nobel N.V.)
参考来源:WO 0112202
📄 详细内容
合成路线:Fischer esterification of 5,5'-methylene-bis-salicylic acid (I) with methanolic HCl gives the dimethyl ester (II).Alkylation of the phenolic hydroxyls of (II) with 2,6-di(bromomethyl)naphthalene (III) affords the bis-naphthylmethyl ether (IV).Then,macrocyclization of dibromide (IV) with a further molecule of 5,5'-methylene-bis-salicylic acid dimethyl ester (II) produces the tetraoxacyclophane derivative (V).Finally,basic hydrolysis of the methyl ester groups of (V) produces the title tetracarboxylic acid.
参考文献标题:Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation
文献作者:Cameron,K.S.; Fielding,L.; Mason,R.; Muir,A.W.; Rees,D.C.; Thorn,S.; Zhang,M.Q.
参考来源:Bioorg Med Chem Lett 2002,12(5),753