新产品编号:207751

Chemical Name: N6-Cyclopropyl-2',3'-didehydro-2',3'-dideoxyadenosine
CAS No. 188525-24-8
项目整合开发状态: Biological Testing
项目研究机构: University of Georgia (Originator), Yale University (Originator)
合成路线:Treatment of 2-amino-6-chloro-9-beta-D-ribofuranosylpurine (I) with acetoxyisobutyryl bromide (II) led to a mixture of acetoxy bromo derivatives (III) and (IV) which,upon reductive treatment with activated zinc,furnished the 2',3'-dehydro compound (V).Deprotection of (V) with K2CO3 in aqueous methanol provided the free nucleoside (VI).Finally,nucleophilic displacement of the chlorine of (VI) with cyclopropylamine (VII) afforded the target compound.