HPH-Pep
Chemical Name: N,N'-(Pyridin-2,6-diyl)bis(carbonyl)bis(L-histidine) dimethyl diester
CAS No. 185031-56-5, 346607-04-3 (hydrate)
项目整合开发状态: Biological Testing
项目研究机构: Kumamoto University (Originator), Kyoto Prefectural University of Medicine (Originator), Osaka Prefecture University (Originator)
合成路线:The title compound has been prepared by two related procedures.2,6-Pyridinedicarboxylic acid (I) was condensed with L-histidine methyl ester (II) using diphenyl phosphoryl azide as the coupling reagent to afford the target diamide.
📌 参考资料/链接：
参考文献标题:An artificial Cu(II) complex with intriguing oxygen radical-quenching profile.X-ray structure,cytochrome c assay,and ESR study
文献作者:Otsuka,M.; Satake,H.; Murakami,S.; Doi,M.; Ishida,T.; Shibasaki,M.; Sugiura,Y.
参考来源:Bioorg Med Chem 1996,4(10),1703
📄 详细内容
合成路线:In an alternative process,acid chloride (III) was condensed with histidine (IV) in the presence of KOH in H2O/THF producing de diamide diacid (V),which was then esterified by treatment with SOCl2 in cold methanol.
参考文献标题:Synthesis of new chiral macrocyclic tetraoxo polyamines containing pyridine ring and functional arms
文献作者:You,J.; et al.
参考来源:Synth Commun 1999,29(14),2447