新产品编号:854789
Chemical Name: 1,1'-O-(1,7-Dioxoheptane-1,7-diyl)-bis[2,3,4,6-tetrakis-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose]
CAS No. 341035-06-1
项目整合开发状态: Preclinical
项目研究机构: Pennsylvania State University (Originator)
合成路线:Selective hydrolysis of the 1-ester group of per-O-benzyl pentagalloylglucopyranose (I) by means of ammonia in MeOH-THF produced the pentagalloyl derivative (II).Coupling of (II) with pimeloyl chloride (III) yielded the bis-glucopyranosyl pimelate ester (IV).
合成路线:The O-benzyl protecting groups of (IV) were removed by catalytic hydrogenation over Pd/C to produce the title compound.
📌 参考资料/链接：
参考文献标题:Gallotannins and ellagitannins as regulators of cytokine release
文献作者:Feldman,K.S.(Penn State Research Foundation)
参考来源:WO 0136436
📄 详细内容
合成路线:Selective hydrolysis of the 1-ester group of per-O-benzyl pentagalloylglucopyranose (I) by means of ammonia in MeOH-THF produced the pentagalloyl derivative (II).Coupling of (II) with pimeloyl chloride (III) yielded the bis-glucopyranosyl pimelate ester (IV).
合成路线:The O-benzyl protecting groups of (IV) were removed by catalytic hydrogenation over Pd/C to produce the title compound.
参考文献标题:In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-alpha production by dimeric gallotannin analogues
文献作者:Feldman,K.S.; Wilson,S.L.; Lawlor,M.D.; Lang,C.H.; Scheuchenzuber,W.J.
参考来源:Bioorg Med Chem 2002,10(1),47