合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:Thiourea inhibitors of herpes viruses
文献作者:Bloom,J.D.; O'Hara,B.M.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.(Wyeth)
参考来源:EP 1137647; JP 2002531557; WO 0034268
合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:Thiourea inhibitors of herpes viruses
文献作者:Bloom,J.D.; O'Hara,B.M.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.(Wyeth)
参考来源:EP 1140913; JP 2002531558; WO 0034269
合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substd.phenylenediamine group
文献作者:Jones,T.R.; Bloom,J.D.; Ross,A.A.; O'Hara,B.M.; Curran,K.J.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.; Terefenko,E.A.(Wyeth)
参考来源:JP 2002533301; US 6166028; WO 0034261
合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:alpha-Methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
文献作者:Bloom,J.D.; Ross,A.A.; O'Hara,B.M.; Curran,K.J.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.; Norton,E.B.(Wyeth)
参考来源:JP 2002531555; WO 0034260
合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group
文献作者:Jones,T.R.; Bloom,J.D.; Ross,A.A.; O'Hara,B.M.; Curran,K.J.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.; Terefenko,E.A.(Wyeth)
参考来源:JP 2002531554; WO 0034258
合成路线:The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III).After Boc group cleavage in (III) by means of trifluoroacetic acid,the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
参考文献标题:Acetamide and substd.acetamide-containing thiourea inhibitors of herpes viruses
文献作者:Bloom,J.D.; O'Hara,B.M.; DiGrandi,M.J.; Dushin,R.G.; Lang,S.A.(Wyeth)
参考来源:JP 2002531544; WO 0034237
产品链接: CAS No. 273735-28-7››