新产品编号:589013

Chemical Name: 6-Amino-2-butyl-9-(4-fluorobenzyl)-9H-purin-8-ol
CAS No. 228107-55-9
项目整合开发状态: Preclinical
项目研究机构: Japan Energy (Originator), Sumitomo Pharmaceuticals (Originator)
合成路线:Condensation of 4-amino-5-cyanoimidazole (I) with pentanamide (II) upon heating at 210 C produced the 2-butyladenine (III).Subsequent alkylation of (III) with 4-fluorobenzyl chloride (IV) yielded the 9-fluorobenzyl adenine (V).This was brominated at position 8 using Br2 and NaOAc in HOAc.The resultant 8-bromo adenine (VI) was finally hydrolyzed under acidic conditions to the title 8-hydroxy derivative.