EM-523
(1S,2R,3S,4S,5R,8R,9S,10R,11R)-8-乙基-2-[(2S,3R,4S,6R)-4-(乙基-甲基氨基)-3-羟基-6-甲基四氢吡喃-2-基]氧基-9,10-二羟基-4-[(2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢吡喃-2-基]氧基-1,3,5,9,11,13-六甲基-7,15-二氧杂双环[10.2.1]十五碳-12-烯-6-酮Chemical Name: 8,9-Didehydro-N-demethyl-N-ethylerythromycin A 6,9-hemiketal; 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-ethylerythromycin
CAS No. 110205-60-2
项目整合开发状态: Phase II
项目研究机构: Kitasato Institute (Originator), Takeda (Originator)
合成路线:By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.
📌 参考资料/链接：
参考文献标题:Erythromycin derivs.and process for preparing the same
文献作者:Omura,S.; Itoh,Z.(Kitasato Institute)
参考来源:AU 8661583; EP 0215355; JP 1988099092; US 5175150
📄 详细内容
合成路线:By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.
参考文献标题:Safety and pharmacokinetics of recombinant CD4 in children with HIV infection
文献作者:Weintrub,P.; et al.
参考来源:Int Conf AIDS 1990,Abst F.B.23
合成路线:By treatment of N-demethyl-N-ethylerythromycin A (I) with glacial acetic acid at room temperature.
合成路线:Title compound was obtained by cyclization of N-demethyl-N-acetyl erythromycin A (I) in glacial AcOH at room temperature.
参考文献标题:Motilides,macrolides with gastrointestinal motor stimulating activity.I.O-Substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal
文献作者:Tsuzuki,K.; Toyoda,H.; Inatomi,N.; Sunazuka,T.; Omura,S.; Marui,S.; Itoh,Z.
参考来源:Chem Pharm Bull 1989,37(10),2687
产品链接: CAS No. 110205-60-2››