Tosifen, Sch-11973
Chemical Name: 4-Methyl-N-[N-[1(S)-methyl-2-phenylethyl]carbamoyl]benzenesulfonamide
CAS No. 32295-48-0
项目整合开发状态: Not Determined
项目研究机构:
合成路线:It can be prepared in several different ways:1) By reaction of d-amphetamine (I) with ethyl N-p-toluenesulfonylcarbamate (II) in refluxing toluene (1).2) By reaction of (I) with p-toluenesulfonyl isocyanate (III) in refluxing toluene (1).3) By reaction of p-toluenesulfinyl chloride (IV) with 3-hydroxy-1-(d-alpha-methyl-phenethyl) urea (V) in refluxing petroleum ether (1).4) By reaction of p-toluenesulfonyl chloride (VI) with N-(d-alpha-methylphenethyl)urea (VII) in refluxing petroleum ether (2).
📌 参考资料/链接：
参考文献标题:
文献作者:Zitowitz,L.; et al.
参考来源:AU 321930; CA 976188; CH 580579; DE 2042230; FR 2068521; GB 1308210; ZA 7005866
📄 详细内容
合成路线:It can be prepared in several different ways:1) By reaction of d-amphetamine (I) with ethyl N-p-toluenesulfonylcarbamate (II) in refluxing toluene (1).2) By reaction of (I) with p-toluenesulfonyl isocyanate (III) in refluxing toluene (1).3) By reaction of p-toluenesulfinyl chloride (IV) with 3-hydroxy-1-(d-alpha-methyl-phenethyl) urea (V) in refluxing petroleum ether (1).4) By reaction of p-toluenesulfonyl chloride (VI) with N-(d-alpha-methylphenethyl)urea (VII) in refluxing petroleum ether (2).
参考文献标题:
文献作者:
参考来源:AU 3230659
合成路线:It can be prepared in several different ways:1) By reaction of d-amphetamine (I) with ethyl N-p-toluenesulfonylcarbamate (II) in refluxing toluene (1).2) By reaction of (I) with p-toluenesulfonyl isocyanate (III) in refluxing toluene (1).3) By reaction of p-toluenesulfinyl chloride (IV) with 3-hydroxy-1-(d-alpha-methyl-phenethyl) urea (V) in refluxing petroleum ether (1).4) By reaction of p-toluenesulfonyl chloride (VI) with N-(d-alpha-methylphenethyl)urea (VII) in refluxing petroleum ether (2).
参考文献标题:Tosifen
文献作者:Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1978,3(7),553