新产品编号:732975
Chemical Name: 8-Chloro-10H-[1]benzofuro[3,2-b]indole-1-carboxylic acid
CAS No. 275377-99-6
项目整合开发状态: Biological Testing
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III).This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.
📌 参考资料/链接：
参考文献标题:Substd.benzofuranoindoles and indenoindoles as novel potassium channel openers
文献作者:Butera,J.A.; Antane,S.A.; Lennox,J.R.(Wyeth)
参考来源:EP 1135393; US 6288099; WO 0034285
📄 详细内容
合成路线:The condensation between 5-chloro-3(2H)benzofuranone (I) and 2-hydrazinobenzoic acid (II) afforded the corresponding hydrazone (III).This was subjected to microwave-promoted Fischer indole cyclization in formic acid to produce the target benzofuroindole tetracyclic system.
参考文献标题:Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole- and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids
文献作者:Butera,J.A.; Antane,S.A.; Hirth,B.H.; Lennox,J.R.; Sheldon,J.H.; Norton,N.W.; Warga,D.; Argentieri,T.M.
参考来源:Bioorg Med Chem Lett 2001,11(16),2093