新产品编号:759869
Chemical Name: [mu-(Ethanethioamidato-kappaN:kappaS)]bis(2,2':6',2''-terpyridine-kappaN1,kappaN1',kappaN1'')diplatinum(3+) trinitrate
CAS No. 289685-03-6, 289685-02-5 (cation)
项目整合开发状态: Biological Testing
项目研究机构: Isis Innovation (Originator)
合成路线:The exchange reaction of (1,5-cyclooctadiene)diiodoplatinum (I) with silver nitrate produced the platinum nitrate derivative (II).Complexation of (II) with 2,2':6',2''-terpyridine (III) produced the terpyridine-platinum complex (IV),which was subsequently treated with thioacetamide (V) to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Platinum(II) cpds.
文献作者:Lowe,G.(Isis Innovation Ltd.)
参考来源:EP 1155025; WO 0050431
📄 详细内容
合成路线:The exchange reaction of (1,5-cyclooctadiene)diiodoplatinum (I) with silver nitrate produced the platinum nitrate derivative (II).Complexation of (II) with 2,2':6',2''-terpyridine (III) produced the terpyridine-platinum complex (IV),which was subsequently treated with thioacetamide (V) to furnish the title compound.
参考文献标题:Human thioredoxin reductase is efficently inhibited by (2,2':6',2''-terpyridine)platinum(II) complexes.Possible implications for a novel antitumor strategy
文献作者:Becker,K.; Herold-Mende,C.; Park,J.J.; Lowe,G.; Schirmer,R.H.
参考来源:J Med Chem 2001,44(17),2784