NG-38

Chemical Name: 9-Isopropyl-N-(4-methoxybenzyl)-2-(perhydroazepin-1-yl)-9H-purin-6-amine
CAS No. 244030-38-4
项目整合开发状态: Biological Testing
项目研究机构: Novartis (Originator)
合成路线:The alkylation of 6-chloro-2-fluoropurine (I) with isopropanol (II) under Mitsunobu conditions gives 6-chloro-2-fluoro-9-isopropylpurine (III),which is regioselectively alkylated at the 6 position with 4-methoxybenzylamine (IV) to yield 2-fluoro-9-isopropyl-N6-(4-methoxybenzyl)adenine (V).Finally,the 2-fluoro position of (V) is aminated with perhydroazepine (VI) in n-butanol at high temperature in a sealed tube to afford the target trisubstituted purine.