FR-66973, FK-973

(1aS,3S,8R,9S,9aS)-1-乙酰基-7,9-二(乙酰氧基)-8-(((氨基羰基)氧基)甲基)-1,1a,2,8,9,9a-六氢-3,9-环氧-3H-氮丙啶并(2,3-c)苯并氮杂环辛四烯-5-甲醛 3,9-环氧-3H-阿锹铉[2,3-c][1]苯扎唑辛-5-羧醛,1-乙酰-7,9-双(乙酰氧)-8-[[(氨基羰基)氧]甲基]-1,1a,2,8,9,9a-六氢-(9CI) Chemical Name: [1aS-(1aalpha,3alpha,8alpha,9aalpha)]-7,9-Diacetoxy-1-acetyl-8-(carbamoyloxymethyl)-3,9-epoxy-5-formyl-1a,2,3,8,9,9a-hexahydro-1H-azirino[2,3-c][1]benzazocine; Carbamic acid (1aS,8R,9aS)-1-acetyl-5-formyl-7,9-diacetoxy-3,9-epoxy-2,3,8,9,9a,9b-hexahydro-1H-azirino[2,3-c][1]benzazocine-8-ylmethyl ester
CAS No. 114580-45-9, 113202-60-1 (error in MF)
项目整合开发状态: Phase II
项目研究机构: Fujisawa (Originator), Lyphomed (Originator)
合成路线:By acetylation of 8-carbamoyloxymethyl-5-formyl-7,9-dihydroxy-3,9-epoxy-1,1a,2,8,9,9a-octahydroazirino[2,3-c][1]benzazocine (FR-900482) (I) with acetic anhydride - pyridine.

合成路线:FR-900482 (I) was produced by culturing Streptomyces sandaensis No.6897 (FERM P-7654) and recovered by conventional methods.The acetylation of (I) with acetic anhydride gave the triacetyl derivative (II),which was selectively deacetylated with NaHCO3 in cool methanol yielding the diacetate (III).Finally,this compound was methylated by means of methyl iodide and K2CO3 in warm acetone.