新产品编号:530479
Chemical Name: 2-(Octylsulfonyl)acetamide
CAS No. 221158-26-5
项目整合开发状态: Biological Testing
项目研究机构: Johns Hopkins University (Originator)
合成路线:Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III).The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid.The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).
📌 参考资料/链接：
参考文献标题:Antimicrobial cpds.
文献作者:Dick,J.D.; Parrish,N.M.; Townsend,C.A.; Kuhajda,F.P.; Pasternack,G.R.(Johns Hopkins University)
参考来源:JP 2001514168; WO 9910321
📄 详细内容
合成路线:Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III).The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid.The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).
参考文献标题:A new class of antituberculosis agents
文献作者:Jones,P.B.; Parrish,N.M.; Houston,T.A.; Stapon,A.; Bansal,N.P.; Dick,J,D.; Townsend,C.A.
参考来源:J Med Chem 2000,43(17),3304
合成路线:Alkylation of methyl thioglycolate (I) with n-octyl bromide (II) gave the octyl thioether (III).The sulfide group was then oxidized to the sulfoxide (IV) by using either hydrogen peroxide in the presence of ammonium molybdate or m-chloroperbenzoic acid.The target amide was finally obtained by ammonolysis of the methyl ester function of (IV).
参考文献标题:In vitro activity of a novel antimycobacterial compound,n-octanesulfonylacetamide,and its effects on lipid and mycolic acid synthesis
文献作者:Parrish,N.M.; Houston,T.A.; Jones,P.B.; Townsend,C.; Dick,J.D.
参考来源:Antimicrob Agents Chemother 2001,45(4),1143