新产品编号:875355
Chemical Name: 2-Amino-6-(3,5-dichlorophenylsulfonyl)benzonitrile
CAS No. 348168-66-1
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Sulfide (III) was obtained by displacing a fluoro group in 2,6-difluorobenzonitrile (I) by 3,5-dichlorothiophenol (II).Subsequent oxidation of sulfide (III) provided sulfone (IV).Finally,amination of (IV) with ammonia in a pressure vessel furnished the target amino benzonitrile.
📌 参考资料/链接：
参考文献标题:2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1
文献作者:Chan,J.H.; Hong,J.S.; Hunter,R.N.III.; Orr,G.F.; Cowan,J.R.; Sherman,D.B.; Sparks,S.M.; Reitter,B.E.; Andrews,C.W.III.; Hazen,R.J.; St Clair,M.; Boone,L.R.; Ferris,R.G.; Creech,K.L.; Roberts,G.B.; Short,S.A.; Weaver,K.; et al.
参考来源:J Med Chem 2001,44(12),1866