新产品编号:375443
Chemical Name: 2-[4-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butoxy]phenyl]imidazo[1,2-a]pyridine
CAS No. 207277-28-9
项目整合开发状态: Biological Testing
项目研究机构: Gedeon Richter (Originator)
合成路线:By condensation of 1-(2-methoxyphenyl)piperazine (I) with 6-[4-(4-chlorobutoxy)phenyl]imidazo[1,2-b]thiazole (II) by means of Na2CO3/NaI in refluxing methyl isobutyl ketone.
合成路线:Coupling between phenol derivative (I) and 1-bromo-4-chlorobutane (II) by means of either Na2CO3/NaI or K2CO3 in refluxing 5-methyl-2-hexanone affords 4-chlorobutoxy derivative (III),which is then converted into the desired product by condensation with (2-methoxyphenyl)piperazine dihydrochloride (IV),either by means of Na2CO3/NaI or with K2CO3 in refluxing 5-methyl-2-hexanone.
📌 参考资料/链接：
参考文献标题:2-Methoxyphenylpiperazine derivs.
文献作者:Laszlovszky,I.; Dom醤y,G.; Ferenczy,G.; Sz醤tay,C.Jr.; Thuroczyn?K醠m醤,E.; Lapis,E.; Trischler,F.; Heged鷖,B.; Auth,F.; Csejtei,M.; K醨p醫i,E.; Kiss,B.; Laszy,J.; Pellioniszn?Par骳zai,M.; Sarkadi,A.; Szab? S.(Gedeon Richter Ltd.)
参考来源:EP 0935599; US 6103724; WO 9818797
📄 详细内容
合成路线:Coupling between phenol derivative (I) and 1-bromo-4-chlorobutane (II) by means of either Na2CO3/NaI or K2CO3 in refluxing 5-methyl-2-hexanone affords 4-chlorobutoxy derivative (III),which is then converted into the desired product by condensation with (2-methoxyphenyl)piperazine dihydrochloride (IV),either by means of Na2CO3/NaI or with K2CO3 in refluxing 5-methyl-2-hexanone.
参考文献标题:Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands
文献作者:Laszlovszky,I.; Acs,T.; Kiss,B.; Domany,G.
参考来源:Pharmazie 2001,56(4),287