新产品编号:843715

Chemical Name: 4-(4-Bromo-3-thienylmethyl)-1H-imidazole fumarate
CAS No. 334917-95-2, 334917-94-1 (free base)
项目整合开发状态: Preclinical
项目研究机构: Johnson & Johnson (Originator)
合成路线:The reaction of 4-bromothiophene-3-carboxylic acid with SOCl2 gives the corresponding acyl chloride (II),which is condensed with N,O-dimethylhydroxylamine (III) to yield the amide (IV).The Grignard condensation of (IV) with 4-imidazolylmagnesium bromide (V) affords the methanone (VI),which is reduced with NaBH4 to the corresponding carbinol (VII).Finally,this alcohol is reduced and deprotected with BH3/Me2S in dichloromethane/THF.