合成路线:By reaction of methyl vinyl ketone (A) with 1,7,8,12b-tetrahydrobenzo[1,2] cyclohepta[3,4,5-d,e]isoquinoline hydrochloride (I) at 100 C to give trans-1,2,4,4a,8,9,13b,14-octahydro-3H-benzo[6,7]cyclopenta[1,2,3-d,e]pyrido[2,1-a]isoquinolin-3-one (II),m.p.163-5 C,which is alkylated with tert-butyllithium in benzene.
参考文献标题:Neuroleptic agents of the benzocycloheptapyridoisoquinoline series.1.Synthesis and stereochemical ans structural requirements for activity of butaclamol and related compounds
文献作者:Bruderlein,T.F.; Humber,L.G.
参考来源:J Med Chem 1975,18(2),186
合成路线:By reaction of methyl vinyl ketone (A) with 1,7,8,12b-tetrahydrobenzo[1,2] cyclohepta[3,4,5-d,e]isoquinoline hydrochloride (I) at 100 C to give trans-1,2,4,4a,8,9,13b,14-octahydro-3H-benzo[6,7]cyclopenta[1,2,3-d,e]pyrido[2,1-a]isoquinolin-3-one (II),m.p.163-5 C,which is alkylated with tert-butyllithium in benzene.
参考文献标题:The synthesis and sterreo-chemistry of teclamine hydrochloride,a novel psychotropic agent
文献作者:Bruderlein,T.F.; et al.
参考来源:Can J Chem 1974,522119
合成路线:By reaction of methyl vinyl ketone (A) with 1,7,8,12b-tetrahydrobenzo[1,2] cyclohepta[3,4,5-d,e]isoquinoline hydrochloride (I) at 100 C to give trans-1,2,4,4a,8,9,13b,14-octahydro-3H-benzo[6,7]cyclopenta[1,2,3-d,e]pyrido[2,1-a]isoquinolin-3-one (II),m.p.163-5 C,which is alkylated with tert-butyllithium in benzene.
参考文献标题:N-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)methyl]amides
文献作者:Bruderlein,T.F.; Humber,L.G.
参考来源:FR 2081498; GB 1341109; US 3657250; US 3914305
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