8-OH-DPAT HBr
(±)-8-羟基-2-(二丙基氨基)四氢萘 氢溴酸盐Chemical Name: 8-Hydroxy-2-(di-N-propylamino)tetralin hydrobromide; 7-(Di-N-propylamino)-5,6,7,8-tetrahydro-1-naphthalenol hydrobromide
CAS No. 87394-87-4, 80300-08-9 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Uppsala University (Originator)
合成路线:8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3).Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II).Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III).The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.
📌 参考资料/链接：
参考文献标题:8-OH-DPAT Hydrobromide
文献作者:Arvidsson,L.-E.
参考来源:Drugs Fut 1985,10(11),916
📄 详细内容
合成路线:8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3).Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II).Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III).The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.
参考文献标题:8-Hydroxy-2-(di-n-propylamino)tetralin,a new centrally acting 5-hydroxytryptamine receptor agonist
文献作者:Arvidsson,L.E.; Hacksell,U.; Nilsson,J.L.G.; Hjorth,S.; Carlsson,A.; Lindberg,P.; Sanchez,D.; Wikstr鰉,H.
参考来源:J Med Chem 1981,24(8),921-923
合成路线:8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3).Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II).Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III).The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.
参考文献标题:8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytyptamine receptor agonist
文献作者:Arvidsson,L.E.; Hacksell,U.; Johansson,A.M.; Nilsson,J.L.G.; Lindberg,P.; Sanchez,D.; Wikstr鰉,H.; Svensson,K.; Hjorth,S.; Carlsson,A.
参考来源:J Med Chem 1984,27(1),45-51
产品链接: CAS No. 87394-87-4››