CV-3988
(±)-[3-(N-十八烷基氨基甲酰氧)-2-甲氧基]丙基-2- 噻唑乙基磷酸Chemical Name: (?-3-(4-Hydroxy-7-methoxy-10-oxo-3,5,9-trioxa-11-aza-4-phosphanonacos-1-yl)thiazolium hydroxide,inner salt P-oxide
CAS No. 85703-73-7
项目整合开发状态: Phase II
项目研究机构: Takeda (Originator)
合成路线:The condensation of 2-methoxypropane-1,3-diol (I) with octadecylisocyanate (II) in pyridine gives 3-(N-octadecylcarbamoyloxy)-2-methylpropanol (III),which is esterified with 2-bromoethyl phosphorodichloridate (IV) by means of pyridine in benzene and treated with water to afford 3-(N octadecyicarbamoyloxy)-2-methoxypropyl2-bromoethyl acid phosphate (V).Finally,this compound is treated with thiazole (VI) and Ag2CO3 in hot toluene.
📌 参考资料/链接：
参考文献标题:Carbamic acid esters,their production and use
文献作者:Nomura,H.; Hozumi,M.; Yoshioka,Y.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0035375
📄 详细内容
合成路线:The condensation of 2-methoxypropane-1,3-diol (I) with octadecylisocyanate (II) in pyridine gives 3-(N-octadecylcarbamoyloxy)-2-methylpropanol (III),which is esterified with 2-bromoethyl phosphorodichloridate (IV) by means of pyridine in benzene and treated with water to afford 3-(N octadecyicarbamoyloxy)-2-methoxypropyl2-bromoethyl acid phosphate (V).Finally,this compound is treated with thiazole (VI) and Ag2CO3 in hot toluene.
参考文献标题:CV-3988
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1987,12(1),12
合成路线:The condensation of 2-methoxypropane-1,3-diol (I) with octadecylisocyanate (II) in pyridine gives 3-(N-octadecylcarbamoyloxy)-2-methylpropanol (III),which is esterified with 2-bromoethyl phosphorodichloridate (IV) by means of pyridine in benzene and treated with water to afford 3-(N octadecyicarbamoyloxy)-2-methoxypropyl2-bromoethyl acid phosphate (V).Finally,this compound is treated with thiazole (VI) and Ag2CO3 in hot toluene.
参考文献标题:CV-3988 - A specific antagonist of platelet activa
文献作者:Terashita,Z.; Tsushima,S.; Yoshioka,Y.; Nomura,H.; Inada,Y.; Nishikawa,K.
参考来源:Life Sci 1983,321975
产品链接: CAS No. 85703-73-7››