Chemical Name: 3'-Azido-3'-deoxy-5'-O-(4-hydroxybutyloxycarbonyl)thymidine
CAS No. 313343-81-6
项目整合开发状态: Preclinical
项目研究机构: Laphal (Originator)
合成路线:The desired product can be obtained by condensation of commercial AZT (I) with N,N?carbonyldiimidazole (CDI) in DMF followed by treatment with 1,4-butanediol (II) in the same solvent.
📄 详细内容
合成路线:The desired product can be obtained by condensation of commercial AZT (I) with N,N?carbonyldiimidazole (CDI) in DMF followed by treatment with 1,4-butanediol (II) in the same solvent.
参考文献标题:Novel esters derived from nucleosides,preparation methods and pharmaceutical compsns.containing them
文献作者:Vlieghe,P.; Salles,J.-P.; Clerc,T.; Kraus,J.-L.(Laboratoires Laphal)
参考来源:FR 2796384; WO 0104134
合成路线:The desired product can be obtained by condensation of commercial AZT (I) with N,N?carbonyldiimidazole (CDI) in DMF followed by treatment with 1,4-butanediol (II) in the same solvent.
参考文献标题:New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: Synthesis and anti-HIV evaluation
文献作者:Vlieghe,P.; Bihel,F.; Clerc,T.; Pannecouque,C.; Witvrouw,M.; De clercq,E.; Salles,J.P.; Chermann,J.C.; Kraus,J.L.
参考来源:J Med Chem 2001,44(5),777
合成路线:The desired product can be obtained by condensation of commercial AZT (I) with N,N?carbonyldiimidazole (CDI) in DMF followed by treatment with 1,4-butanediol (II) in the same solvent.
参考文献标题:New 3'-azido-3' deoxythymidin-5'-yl O-(4-hydroxyalyl or -alkenyl or -alkylepoxide) carbonate prodrugs: Synthesis and anti-HIV evaluation
文献作者:Vlieghe,P.; Clerc,T.; Pannecouque,C.; Witvrouw,M.; De Clercq,E.; Salles,J.-P.; Kraus,J.-L.
参考来源:J Med Chem 2001,44(18),3014