新产品编号:835805

Chemical Name: 3-O-(3,3-Dimethylsuccinyl)-28-O-(2,2-dimethylsuccinyl)lup-20(29)-en-3beta,28-diol
CAS No. 332346-42-6
项目整合开发状态: Biological Testing
项目研究机构: BBI Biotech Research Laboratories (Originator)
合成路线:Reaction of betulin (I) and 2,2-dimethylsuccinic acid (II) in refluxing pyridine,followed by HPLC separation of the two products obtained,affords derivative (III).Protection of the carboxylic group of (III) is then performed by formation of the corresponding allyl ester derivative (V) by reaction with allyl bromide (IV) and K2CO3 in acetone.Separately,2,2-dimethylsuccinic acid (II) is treated with allyl alcohol (VI) in refluxing pyridine to give an isomeric mixture of compounds from which allyl succinate derivative (VII) is chromatographically isolated.Formation of the corresponding acid chloride (VIII) is finally performed by treatment of (VII) with (COCl)2 in refluxing benzene.Condensation between alcohol (V) and acid chloride (VIII) by means of DMAP in CH2Cl2 provides compound (IX),which is finally converted into the target product by removal of the allyl protecting groups by means of Pd(Ph3P)4 and morpholine.