新产品编号:807329

Chemical Name: Diaqua[N,N',N''-[nitrilotris[1(R)-(hydroxymethyl)-2,1-ethylanediyl]]tris[3-(hydroxy-kappaO)-1-methyl-2-(oxo-kappaO)-1,2-dihydropyridine-4-carboxamidato]](3-)]gadolinium
CAS No. 315181-39-6
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Torino (Originator), Universit?degli Studi Piemonte Orient. (Originator), University of California, Berkeley (Originator)
合成路线:The reductive condensation of ammonium acetate with three molecules of N-Boc-O-benzyl-L-serinal (I) in the presence of sodium triacetoxyborohydride produced the tertiary amine (II).Subsequent removal of the Boc protecting groups of (II) by means of trifluoroacetic acid gave the tetra-amine (III).This was coupled with the (pyridylcarbonyl)thiazolidinethione (IV) to furnish the tris-pyridinecarboxamide (V).Cleavage of the benzyl ether groups of (V) was achieved by treatment of (V) with HBr in AcOH to yield (VI).This was finally complexed with Gd+3 ion to form the title gadolinium chelate.