CFM-1571
Chemical Name: 1-Benzyl-3-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
CAS No. 268725-86-6
项目整合开发状态: Preclinical
项目研究机构: Tripos (Originator), University College London (Originator)
合成路线:Condensation of 1-benzyl-3-hydroxy-1H-pyrazole-5-carboxylic acid methyl ester (I) with 3-(dimethylamino)-1-propanol (II) by means of 1,1'-(azodicarbonyl)dipiperidine and tributylphosphine under Mitsunobu conditions afforded the dimethylaminopropyl ether (III).After basic hydrolysis of the methyl ester group of (III),the resultant carboxylic acid (IV) was coupled with 4-methoxyaniline (V) using HATU to furnish the title amide.
📌 参考资料/链接：
参考文献标题:Activators of soluble guanylate cyclase
文献作者:Glen,R.; Liu,Q.; Powell,K.; Reynolds,K.; Madge,D.; Kling,M.; Selwood,D.; Wishart,G.(University College London)
参考来源:WO 0027394
📄 详细内容
合成路线:Condensation of 1-benzyl-3-hydroxy-1H-pyrazole-5-carboxylic acid methyl ester (I) with 3-(dimethylamino)-1-propanol (II) by means of 1,1'-(azodicarbonyl)dipiperidine and tributylphosphine under Mitsunobu conditions afforded the dimethylaminopropyl ether (III).After basic hydrolysis of the methyl ester group of (III),the resultant carboxylic acid (IV) was coupled with 4-methoxyaniline (V) using HATU to furnish the title amide.
参考文献标题:Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor,soluble guanylate cyclase
文献作者:Selwood,D.L.; Brummel,D.G.; Budworth,J.; Burtin,G.E.; Campbell,R.O.; Chana,S.S.; Charles,I.G.; Fernandez,P.A.; Glen,R.C.; Goggin,M.C.; Hobbs,A.J.; Kling,M.R.; Liu,Q.; Madge,D.J.; Meillerais,S.; Powell,K.L.; Reynolds,K.; et al.
参考来源:J Med Chem 2001,44(1),78
产品链接: CAS No. 268725-86-6››