MnTDE-2-ImP5+, AEOL-10150

Chemical Name: (SP-4-1)-[[2,2',2'',2'''-(21H,23H-Porphine-5,10,15,20-tetrayl-.kappaN21,.kappaN22,.kappaN23,.kappaN24)tetrakis[1,3-diethyl-1H-imidazoliumato]](2-)manganese(5+) pentachloride
CAS No. 286475-30-7
项目整合开发状态: IND Filed
项目研究机构: Aeolus Pharmaceuticals (Orphan Drug), National Jewish Center (Originator), Aeolus Pharmaceuticals (Licensee)
合成路线:The tetraimidazolyl porphyrin (III) was prepared by reaction between 1-ethylimidazole-2-carboxaldehyde (I) and pyrrole (II) in refluxing propionic acid.Quaternization of the imidazole groups of (III) with iodoethane furnished the tetrakis-imidazolium iodide salt (IV).After complexation of porphyrin (IV) with manganese(III) acetate,its precipitation as the hexafluorophosphate salt followed by anion exchange with tetrabutylammonium chloride,furnished the title chelate pentachloride salt.