AC-165024

Chemical Name: N-Cyclooctyl-N-[1-[3-(4-fluorophenoxy)propyl]piperidin-4-yl]propanamide
CAS No. 319428-14-3
项目整合开发状态: Biological Testing
项目研究机构: ACADIA (Originator)
合成路线:The reductive alkylation of cyclooctylamine (II) with N-Boc-4-piperidinone (I) in the presence of sodium cyanoborohydride afforded the secondary amine (III),which was condensed with propionyl chloride,yielding amide (IV).Deprotection of the Boc group of (IV) by means of HCl in dioxan provided piperidine (V).This was finally alkylated with 1-(3-chloropropoxy)-4-fluorobenzene (VI) to furnish the title compound.