R-123942

Chemical Name: N-[1-[6-(1,2,4-Thiadiazol-5-yl)pyridazin-3-yl]piperidin-4-yl]-N-[3-(trifluoromethyl)phenyl]amine
CAS No. 193957-04-9
项目整合开发状态: Preclinical
项目研究机构: Janssen (Originator)
合成路线:Treatment of 3-chloro-6-methylpyridazine (I) with thionyl chloride followed by reaction with imino derivative (II) in CH2Cl2 provides thiadiazolyl pyridazine derivative (III),which is then condensed with amine (IV) in the presence of Na2CO3 in DMF.