(R)-HI-511
Chemical Name: N-(5-Bromopyridin-2-yl)-N'-[1(R)-phenylethyl]thiourea
CAS No. 307317-61-9
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Condensation of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) gave rise to thioimidazolide (III),which was then condensed with (R)-1-phenylethylamine (IV) to yield the title thiourea.
📌 参考资料/链接：
参考文献标题:Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase
文献作者:Venkatachalam,T.K.; Sudbeck,E.A.; Mao,C.; Uckun,F.M.
参考来源:Bioorg Med Chem Lett 2000,10(18),2071