新产品编号:962365
Chemical Name: 6-(N-Ethyl-N-propylamino)-1,2,3,4,5,6,7,8-octahydronaphthalen-1-one
CAS No. 500548-85-6
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Condensation of 1,2,3,4,5,6,7,8-octahydronaphthalene-1,6-dione (I) with N-ethyl propylamine (II) affords dienaminone (III).This is then reduced to the target compound employing NaBH3CN in the presence of AcOH.
📌 参考资料/链接：
参考文献标题:Orally active analogues of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro- 2H-naphthalen-1-one: Synthesis and pharmacological activity
文献作者:Venhuis,B.J.; Dijkstra,D.; Wustrow,D.J.; Meltzer,L.T.; Wise,L.D.; Johnson,S.J.; Heffner,T.G.; Wikstr鰉,H.V.
参考来源:J Med Chem 2003,46(4),584