3beta,7beta,17beta-Androstenetriol, HE-2200, Reversionex

Chemical Name: 5-Androstene-3beta,7beta,17beta-triol
CAS No. 62357-04-4 (undefined stereochem.)
项目整合开发状态: Phase II
项目研究机构: Virginia Commonwealth University (Originator), Hollis-Eden (Licensee)
合成路线:Allylic oxidation of 3-beta-17-beta-diacetoxyandrost-5-ene (I) by means of chromic acid provides the unsaturated ketone (II).Stereoselective reduction of enone (II),with concomitant hydrolysis of the acetate esters in the presence of aluminum isopropoxide under Meerwein-Ponndorf-Verley conditions leads to the title trihydroxy steroid.