MEB
Chemical Name: Butyric acid 2-(4-morpholinyl)ethyl ester hydrochloride
CAS No. 23866-07-1, 300555-03-7 (free base)
项目整合开发状态: Preclinical
项目研究机构: University of Arkansas (Originator)
合成路线:The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II),followed by isolation as the corresponding hydrochloride salt.
📌 参考资料/链接：
参考文献标题:Derivs.of butyric acid and uses thereof
文献作者:Gilbert,K.; Fifer,E.K.(University of Arkansas)
参考来源:US 6407107; WO 0073257
📄 详细内容
合成路线:The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II),followed by isolation as the corresponding hydrochloride salt.
参考文献标题:Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation
文献作者:Gilbert,K.M.; Wahid,R.; Fecher,N.P.; Freeman,J.P.; Fifer,E.K.
参考来源:J Pharmacol Exp Ther 2000,294(3),1146
合成路线:The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II),followed by isolation as the corresponding hydrochloride salt.
参考文献标题:Synthesis of hydrochlorides of N-ethanolmorpholine esters and aliphatic acids
文献作者:Chrzaszczewska,A.; Starksi,H.
参考来源:Soc Sci Lodz Acta Chim 1967,12133