NNC-21-0300

Chemical Name: 5'-Deoxy-2,5'-dichloro-N6-[4-(2-pyridylsulfanyl)piperidin-1-yl]adenosine
CAS No. 206270-32-8
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:The N-amination of 4-(2-pyridylthio)piperidine (I) with hydroxylamine O-sulfonic acid afforded hydrazine (II).This was condensed with dichloropurine derivative (III) to yield the piperidinyl adenosine (IV).Deacetylation of (IV) by treatment with methanolic ammonia gave (V).Finally,the primary hydroxyl group of (V) was converted to the title chloride by reaction with SOCl2 in the presence of pyridine.