TAK-457

Chemical Name: 4-(Acetoxymethyl)-1-[2(R)-(2,4-difluorophenyl)-2-hydroxy-3(R)-[2-oxo-3-[4-(1H-tetrazol-1-yl)phenyl]imidazolidin-1-yl]butyl]-1H-1,2,4-triazol-4-ium chloride
CAS No. 214543-30-3, 214543-28-9 (bromide salt)
项目整合开发状态: Preclinical
项目研究机构: Takeda (Originator)
合成路线:The alkylation of the triazole derivative (I) (compound 293408) with bromomethyl acetate (II) in hot acetonitrile produced the triazolium bromide salt (III).This was then treated either with ion-exchange resin or with a saturated solution of NaCl to produce the desired chloride salt.The analogous alkylation of (I) with iodomethyl acetate (IV) produced the iodide salt (V),which was finally converted to the corresponding chloride by treatment with a saturated solution of NaCl.