新产品编号:775689
Chemical Name: 6-Chloro-5-methyl-N-[6-(2-methylpyridin-3-yloxy)pyridazin-3-yl]indoline-1-carboxamide
CAS No. 300554-31-8
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Condensation between 3-amino-6-chloropyridazine (I) and 3-hydroxy-2-methylpyridine (II) in aqueous NaOH at 175 C under pressure afforded the bisaryl ether (III).The phenyl carbamate (IV) was then prepared by treatment of aminopyridazine (III) with phenyl chloroformate.Finally,coupling of carbamate (IV) with 6-chloro-5-methylindoline (V) yielded the title urea derivative.
📌 参考资料/链接：
参考文献标题:1-[2-(Heteroaryloxy)heteroaryl]carbamoy]indolines: Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents
文献作者:Bromidge,S.M.; Dabbs,S.; Davies,S.; Duckworth,D.M.; Forbes,I.T.; Jones,G.E.; Jones,J.; King,F.D.; Saunders,D.V.; Blackburn,T.P.; Holland,V.; Kennett,G.A.; Lightowler,S.; Middlemiss,D.N.; Riley,G.J.; Trail,B.; Wood,M.D.
参考来源:Bioorg Med Chem Lett 2000,10(16),1863