新产品编号:791509
Chemical Name: (2RS,3SR)-1,2-Dimethyl-3-(2-naphthyl)pyrrolidin-3-ol hydrochloride
CAS No. 302959-32-6
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The target (rac)-(cis)-compound is prepared by reaction of the pyrrolidone (II) with the lithiation product obtained by treating the 2-bromo naphthalene (I) in ether with t-BuLi in pentane and by successive treatment with HCl.
📌 参考资料/链接：
参考文献标题:Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes
文献作者:Collina,S.; Azzolina,O.; Vercesi,D.; Sbacchi,M.; Sheideler,M.A.; Barbieri,A.; Lanza,E.; Ghislandi,V.
参考来源:Bioorg Med Chem 2000,8(8),1925